Endocrine Abstracts

During recent years, insulin and insulin-like growth factors have been implicated in the control of lifespan in a variety of species. In mammals, substantial reduction of somatotropic signals generally extends lifespan. We showed recently in a conditional mouse mutant relevant for humans, that lifespan can be prolonged by inhibiting IGF-I signaling selectively in the central nervous system. This effect occurred through changes in specific neuroendocrine pathways. Investigating...